Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor

Tumor Growth Characteristics of the Walker 256 AR Tumor, a Regressive Variant of the Rat Walker 256 A tumor

The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10 W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (...

Cytopathogenic effects of ethylenephosphoramides upon the Walker 256 rat tumor.

In the course of studies dealing with metabolic effects of ethylenephosphoramide chemotherapy upon host and tumor tissues (2, 3, 14, 15), certain cytopathogenic effects were noted in sections of treated Walker 256 rat tumors. The changes con sisted of the appearance of large, polymorphic giant cells with bizarre nuclear and cytoplasmic configurations and unusual staining properties. Changes sim...

Serum polysaccharide levels in rats bearing the Walker 256 tumor.

Previous work on human subjects (9) has shown that the polysaccharide associated with serum proteins is significantly elevated in malig nancy. Little is known concerning the correlation between this elevation and the cancerous condi tion. Work in this laboratory has shown that the serum polysaccharide of dogs is increased in sev eral types of experimental inflammation (7). An elevation also occ...

Dynamic changes of urine proteome in a Walker 256 tumor‐bearing rat model

Despite advances in cancer treatments, early diagnosis of cancer is still the most promising way to improve outcomes. Without homeostatic control, urine reflects systemic changes in the body and can potentially be used for early detection of cancer. In this study, a tumor-bearing rat model was established by subcutaneous injection of Walker 256 cells. Urine samples from tumor-bearing rats were ...

The effect of protein depletion on the host response to transplantable rat tumor Walker 256.